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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Behav Brain Res. 2016 Mar 21;307:218–226. doi: 10.1016/j.bbr.2016.03.035

Figure 1. Daily Voluntary Wheel Running Activity (VWRA).

Figure 1

A. 800 cGy daily radiation dose × 3 produced more pronounced fatigue behavior compared to 600 cGy daily radiation dose × 3, and sham controls in pilot trial 2. B. Validation trial 1 revealed significant decrease in distance (kilometers) for mice irradiated with 800 cGy daily radiation dose × 3. C. Validation trial 2 further confirms the development of fatigue behavior following irradiation with 800 cGy daily radiation dose × 3. The daily mean VWRA distance prior to irradiation days (days 13–15) reflect the VWRA distance covered during running wheel (RW) acclimation. Mice were allowed to rest in home cages on days 13–15 and during saccharin preference testing (days 24–26) in validation trial 1. Error bars show standard error of the mean. *p<0.05, **p<0.001.