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Immunogenicity of L2-VLPs in rats. Rats were immunized thrice orally with 400 μg of VLPs in a) coated or uncoated capsules or b) immunized intramuscularly with 10 μg of VLPs. Two weeks after the last immunization, sera were collected. In a), 1:40 serum dilution was used in an ELISA and b) antibodies titers were determined by end-point dilution ELISA.
