Skip to main content
. Author manuscript; available in PMC: 2017 May 2.
Published in final edited form as: Mol Pharm. 2016 Apr 11;13(5):1646–1655. doi: 10.1021/acs.molpharmaceut.6b00072

Figure 8.

Figure 8

Immunogenicity of stored spray dried L2-VLPs. VLPs were prepared by spray drying and stored at 37°C or RT (21–23 °C) for 14 months. After this period, VLPs were reconstituted in PBS and used to immunize mice. Mice were given a single dose of 5 μg VLPs. A control group was immunized with freshly made L2-VLPs. Sera was collected 1, 2, and 3 months after immunization and anti-L2 IgG titers were determined by end-point dilution ELISA. Each dot refers to an individual immunized mice, lines denote geometric mean IgG titers.