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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Antiviral Res. 2015 Jul 29;122:39–45. doi: 10.1016/j.antiviral.2015.07.008

Figure 1.

Figure 1

NITD008 protects against lethal challenge with WNV. (A–C) C57BL/6 mice inoculated with 1000 PFU WNV (NY99) via footpad injection were administered with different doses of NITD008 via oral gavage twice per day from day 1 to 6 after inoculation and observed for clinical symptoms and mortality. Clinical score criteria: 1, ruffled fur; 2, ruffled fur with distinct hunched back; 3, paresis/difficulty walking; 4, paralysis; 5, moribund/euthanized; (D) WNV titers measured in the serum at day 3 after infection using plaque assay. Error bar represent ± SEM from at least 4 mice/group. **p< 0.005, *p<0.05