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NITD008 blocks WNV dissemination to peripheral tissues and brain. WNV-infected mice treated with vehicle or 10 mg/kg NITD008 on days 1–6 after inoculation were sacrificed at day 5 (spleen and kidney) and day 8 (brain) after infection and WNV titers were analyzed in the tissue homogenates using plaque assay. Dotted line- detection limit of plaque assay. Error bar represent ± SEM from at least 4 mice/group. *p<0.05
