Table 4.
Simulation results for average exposure during critical period of susceptibility in the past (exposure metric iii.1) (500 replicates)
| β | a | Sample Size |
Event %# |
Test %reject |
β̂ | â | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MLE† | Str-Eff* | MLE | Str-Eff* | |||||||||
| mean | CR | mean | mean | median(25th,75th)** | CR | mean | median(25th,75th)** | |||||
| 0.3 | 5 | 10,000 | 25% | 0.760 | 0.301 | 0.95 | 0.326 | 5.7 | 5 (4, 6) | 0.95 | 20.5 | 13 (7, 34) |
| 50,000 | 1.000 | 0.300 | 0.94 | 0.308 | 5.0 | 5 (5, 5) | 0.97 | 15.6 | 8 (6, 22) | |||
| 100,000 | 1.000 | 0.300 | 0.95 | 0.305 | 5.0 | 5 (5, 5) | 0.96 | 12.5 | 7 (6, 11) | |||
| 50,000 | 5% | 0.802 | 0.302 | 0.95 | 0.326 | 5.6 | 5 (4, 6) | 0.94 | 21.7 | 17 (7, 35) | ||
| 100,000 | 0.984 | 0.302 | 0.94 | 0.317 | 5.2 | 5 (5, 5) | 0.96 | 19.4 | 11 (7, 32) | |||
| 10 | 10,000 | 25% | 0.352 | 0.300 | 0.97 | 0.335 | 12.7 | 11 (10, 13) | 0.90 | 27.5 | 24 (13, 42) | |
| 50,000 | 0.960 | 0.305 | 0.94 | 0.318 | 11.3 | 11 (11, 12) | 0.96 | 26.9 | 22 (14, 41) | |||
| 100,000 | 0.998 | 0.305 | 0.92 | 0.312 | 11.2 | 11 (11, 11) | 0.96 | 23.9 | 16 (13, 36) | |||
| 50,000 | 5% | 0.342 | 0.299 | 0.95 | 0.333 | 12.7 | 11 (10, 13) | 0.92 | 28.4 | 27 (14, 42) | ||
| 100,000 | 0.632 | 0.300 | 0.95 | 0.324 | 12.0 | 11 (11, 13) | 0.92 | 27.6 | 23 (14, 43) | |||
| 25 | 10,000 | 25% | 0.400 | 0.299 | 0.93 | 0.321 | 24.6 | 25 (19, 32) | 0.85 | 33.8 | 33 (26, 42) | |
| 50,000 | 0.984 | 0.303 | 0.93 | 0.308 | 25.6 | 25 (23, 27) | 0.91 | 34.5 | 32 (27, 42) | |||
| 100,000 | 1.000 | 0.302 | 0.95 | 0.307 | 25.1 | 25 (24, 26) | 0.96 | 34.2 | 32 (27, 40) | |||
| 50,000 | 5% | 0.422 | 0.302 | 0.92 | 0.325 | 25.4 | 25 (19, 31) | 0.88 | 35.2 | 35 (27, 43) | ||
| 100,000 | 0.746 | 0.302 | 0.92 | 0.314 | 25.6 | 25 (22, 29) | 0.88 | 34.7 | 33 (27, 42) | |||
| 35 | 10,000 | 25% | 0.310 | 0.292 | 0.89 | 0.320 | 28.4 | 32 (18, 38) | 0.87 | 39.8 | 41 (35, 49) | |
| 50,000 | 0.954 | 0.305 | 0.90 | 0.311 | 35.8 | 36 (33, 38) | 0.88 | 42.3 | 42 (37, 48) | |||
| 100,000 | 1.00 | 0.304 | 0.93 | 0.308 | 35.9 | 36 (34, 38) | 0.89 | 43.2 | 43 (38, 49) | |||
| 50,000 | 5% | 0.344 | 0.299 | 0.91 | 0.327 | 25.6 | 26 (20, 32) | 0.82 | 36.6 | 37 (28, 48) | ||
| 100,000 | 0.638 | 0.299 | 0.89 | 0.314 | 33.0 | 35 (28, 40) | 0.84 | 42.0 | 43 (37, 48) | |||
| 0.0 | 10,000 | 25% | 0.046 | 0.002 | 0.97 | 0.005 | N/A | |||||
| 50,000 | 0.058 | 0.000 | 0.95 | 0.000 | N/A | |||||||
| 100,000 | 0.055 | 0.000 | 0.95 | 0.000 | N/A | |||||||
| 50,000 | 5% | 0.046 | −0.001 | 0.97 | 0.001 | N/A | ||||||
| 100,000 | 0.053 | −0.002 | 0.97 | −0.002 | N/A | |||||||
Time range is (0, 50), and exposure is available at t = 0, 1, …, 50. For notations in the table header, see the footnotes of Table 3.