Table 1.

Overview of the in vivo effects of RFRP-3 on reproduction in seasonal mammals.

Species	Sex and status	Effects of RFRP-3	Reference
Siberian hamster	Male	Central administration inhibits LH release in LP	(7)
		Central administration stimulates LH release in SP
Syrian hamster	Male	Central acute and continuous administration stimulates LH release in LP and SP. No peripheral effect	(6)
	Female OVX	Central and peripheral administration (GnIH) inhibits LH release in LP	(84)
Sheep	Female	Peripheral injection or a 4-h perfusion has no effect on kisspeptin-mediated increase in LH in LP	(89)
		Peripheral administration inhibits LH release in SP	(107)
	Female OVX	Repeated peripheral injection has no effect on pulsatile LH release in LP. 24-h perfusion has no effect on E2-induced LH surge in SP	(89)
		Central and peripheral administration has no effect on LH release in SP and LP	(88)
		Peripheral administration inhibits E2-induced LH surge in SP	(81)
		Peripheral administration inhibits pulsatile LH release in SP	(107)
		Peripheral administration inhibits GnRH-induced LH release. RFRP-3 is detected in the portal blood in SP and LP, with higher conc. detected in LP	(109)