Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Apr 26;7:11312. doi: 10.1038/ncomms11312

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(a) Chemical structures for GlcNAc and its derivatives. (b) Western blots for chondroitin-4-sulfate (sidechains) and stub chondroitin-4-sulfate (core proteins) show a concentration-dependent decrease in total CSPG content with fluorosamine treatment. (c) Chemical structures of four derivatives of fluorosamine with various substitutions to carbon-1 and carbon-4. (d) The 1-hydroxy and 1-propanoic fluorosamine derivatives were effective at reducing CSPG synthesis, whereas the 4-methoxy and 1-hydroxy-4-chloro compounds were ineffective. The results are presented as an individual experiment that was conducted three times.