Figure 4. PD-1 decoy potentiates anti-tumor therapeutic efficacy of adoptively transferred T cells. B6 mice were injected with OVA-expressing E.G7 cells (2×106) subcutaneously. After 7 days, the mice were either left untreated or intravenously injected with control vector (pMIG-w)-transduced (2×10 6) or PD-1 decoy-transduced (2×106) OT-I cells. The retrovirus-transduced OT-I cells were rested for 3 days before adoptive transfer. The mean tumor size of 10 mice per group was recorded (*p=0.0039, Wilcoxon matched-pairs test). Results are representative of 2 independent experiments.
