Fig. 1. Study scheme. The study was a 20-week, double-blind, randomized, placebo-controlled trial with a crossover design and a 2-week washout after visit 4. The SCORAD index, and urinary leukotriene E4 (LTE4) and eosinophil-derived neurotoxin (EDN) were assessed at every visit. CBC and blood chemistry were checked at visits 2 and 4.
