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. 2015 Jun 30;75(5):916–923. doi: 10.1136/annrheumdis-2014-206996

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This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

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Patients with ankylosing spondylitis (AS) carrying protective endoplasmic reticulum aminopeptidase 1 variants, K528R or Q730E, have lower monocyte human leucocyte antigen (HLA) class I free heavy chain (FHC) expression. HC-10 antibody (HLA class I FHCs) and ME-1 antibody (classical β2m-associated HLA-B27, B7, B42, B67, B73 and Bw22) staining of CD14+ monocyte, CD19+ B cell and CD3+ T cell from peripheral blood mononuclear cells in patients with AS are shown. HC-10 staining, ME-1 staining and HC-10/ME-1 are compared between patients with AS with different genotypes of rs30187 (TT, CT, CC) in (A) and rs27044 (GG, CG, CC) in (B). Risk alleles and corresponding amino acids are underlined. Results are expressed as mean and SE of mean, p value was determined by Mann-Whitney test (*p<0.05, **p<0.01). Insufficient HLA-B27+ healthy controls were available for comparison.