Table 1. Relationship between clinicopathologic parameters and lymph node metastasis in 202 submucosal invasive gastric carcinomas: results of univariate analysis.
| Parameters | Total | Status of LN metastasis | P value | ||
|---|---|---|---|---|---|
| Negative | Positive | ||||
| Total | 202 | 167 | 35 | ||
| Age | mean ± SD | 61.4 ± 11.6 | 61.7 ± 11.4 | 59.7 ± 13.0 | 0.352 |
| range | 30-85 | 30-85 | 32-77 | - | |
| Sex | M | 131 (64.9%) | 111 (66.5%) | 20 (57.1%) | - |
| F | 71 (35.1%) | 56 (33.5%) | 15 (42.9%) | 0.293 | |
| Family history of cancer | no | 156 (79.6%) | 133 (82.6%) | 23 (65.7%) | - |
| yes | 40 (20.4%) | 28 (17.4%) | 12 (34.3%) | 0.025 | |
| gastric cancer | 24 (12.2%) | 17 (10.6%) | 7 (20.0%) | 0.152 | |
| N/A | 6 | 6 | 0 | - | |
| Tumor size | median (IQR) | 3.0 (2.08-4.5) | 3.0 (2.0-4.0) | 3.6 (2.8-6.0) | 0.004 |
| > 3 cm | 98/202 (48.51%) | 74/167 (44.31%) | 24/35 (68.57%) | 0.015 | |
| 2010 WHO Classification | tubular (all) | 119 (58.9%) | 104 (62.3%) | 15 (42.9%) | - |
| tubular (p/d) | 16 (7.9%) | 14 (8.4%) | 2 (5.7%) | - | |
| mixed | 56 (27.7%) | 41 (24.6%) | 15 (42.9%) | - | |
| pcc | 18 (8.9%) | 15 (9.0%) | 3 (8.6%) | - | |
| mucinous | 2 (1.0%) | 1 (0.6%) | 1 (2.9%) | - | |
| medullary | 7 (3.5%) | 6 (3.6%) | 1 (2.9%) | 0.142 | |
| Presence of PCC component | 75 (37.1%) | 56 (33.5%) | 19 (54.3%) | 0.021 | |
| Lauren classification | intestinal | 116 (60.9%) | 108 (64.7%) | 15 (42.9%) | - |
| diffuse | 62 (30.7%) | 48 (28.7%) | 14 (40.0%) | - | |
| mixed | 17 (8.4%) | 11 (6.6%) | 6 (17.1%) | 0.026 | |
| Depth of invasion | median (IQR) | 1,298 (656-2,220) | 1,200 (555-2,035) | 1,850 (1,050-2,500) | 0.059 |
| > 500 µm | 160 (79.2%) | 132 (79.0%) | 28 (80.0%) | 0.899 | |
| sm1 | 57 (29.7%) | 48 (30.2%) | 9 (27.3%) | - | |
| sm2 | 54 (28.1%) | 50 (31.4%) | 4 (12.1%) | - | |
| sm3 | 81 (42.2%) | 61 (38.4%) | 20 (60.6%) | - | |
| NA | 10 | 8 | 2 | 0.074 | |
| Lymphatic invasion | present | 61 (30.2%) | 33 (19.8%) | 28 (80.0%) | < 0.001 |
LN, lymph node; SD, standard deviation; N/A, not available; IQR, interquartile range; p/d, poorly differentiated; pcc, poorly cohesive carcinoma; PCC component, signet ring/poorly cohesive cellular histological component.