Table 3.

Mutations in the hepatitis B virus preC/C region related to clinical severance

Regions	Mutations				HBV genotype	MHC class	Clinical significance (P value)	Ref.
	Amino acid	Changes	Nucleotide	Changes
preCore	28	W28Stop	1896	G1896A	C2		HCC (n = 12) vs Mild (n = 5) (P = 0.093)	[27]
					A/D		HCC (P < 0.05), FHF (45.0%) vs AVH (17.4%) (P = 0.038)	[72]
Core	5	P5T/L/H	1913-1915	C1913A, C1914A/T, G1915A/C	C2	II	HCC (n = 5) vs Mild (n = 0) (P = 0.02)	[27]
		NC	1915	G1915A/C	C3		HCC (P = 0.020)	[70]
		P5R	1914	C1914G	C4		HCC (32.2%) vs ASC (5.0%)/CHB (7.8%)/LC (10.3%) (P < 0.05)	[72]
	78	NC	2134	C2134T	C5	Immuno-inactive	HCC (P = 0.001)	[70]
	83	E83D	2149	A2149T/C	C6	II	HCC (n = 4) vs Mild (n = 0) (P = 0.039)	[27]
	92	NC	2176	T2176C	C7	I and II	HCC (P = 0.139)	[70]
	97	I97F/L	2189-2191	A2189T/C, C2191T	C8	II	HCC (n = 13) vs Mild (n = 4) (P = 0.024)	[27, 73, 93]
	100	L100I	2198	C2198A	C9	II	HCC (n = 6) vs Mild (n = 1) (P = 0.046)	[27]
	107	NC	2221	C2221T	C10	Immuno-inactive	HCC (P = 0.001)	[70]
	115	NC	2245	C2245T	C11	Immuno-inactive	HCC (P = 0.007)	[70]
	130	P130T	2288	C2288A	C12	I and II	HCC (P = 0.022)	[70]
	182	Q182K/Stop	2444-2445	C2444A/T, A2445G	C13	Immuno-inactive	HCC (n = 4) vs Mild (n = 0) (P = 0.039)	[27]

ASC: Asymptomatic S antigen carrier; AVH: Acute viral hepatitis; CHB: Chronic hepatitis B; FHF: Fulminant hepatic failure; HCC: Hepatocellular carcinoma; LC: Liver cirrhosis; MHC: Major histocompatibility Complex; NC: No change.