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. 2016 May 3;6:25203. doi: 10.1038/srep25203

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Copyright © 2016, Macmillan Publishers Limited

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DP (CAY10595) and PPARγ (GW9662) antagonists were applied directly on IEC cultivated alone, on IEC co-cultivated with Control EGC or on IEC co-cultivated with CD EGC during three days. Quantification of epithelial healing was calculated as the difference between the percentage of healing between t0 and 48 h for co-cultures and the percentage of healing between t0 and 48 h for Caco-2 cultivated alone (b) CAY10595 and GW996 were also added to IEC culture in presence of 11βPGF₂α. Quantification of epithelial healing was calculated as a percentage of healing between t0 and 48 h and compared to 11βPGF₂α healing considered as one. n = 4–7 independent experiments; Kruskal-Wallis test; *p < 0.05; **p < 0.01 as compared to without treatment.