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. 2016 May 3;6:25044. doi: 10.1038/srep25044

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Copyright © 2016, Macmillan Publishers Limited

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(a) In vivo weighted MRI of the thorax after intravenous application of human thrombin (left panel) and injection of Control-MPIO (right panel, above) or LIBS-MPIO (right panel below). Right panel show extracted overlay of edema (gray zone) and MPIO-induced signal decay within this area (pseudo-colored pink-yellow). Below, 3D map of edema after thrombin and corresponding signal overlay after injection of LIBS-MPIO in the murine lung. (b) Edema area after thrombin injection in LIBS-MPIO or Control-MPIO group does not differ (6 mice per group, ns = not significant). (c) Percent change of signal intensity in human thrombin-induced edema after injection of LIBS-MPIO or Control-MPIO (n = 6 mice per group, p < 0.05, Mann-Whitney U Test). (d) Mean number of MPIO found per immunohistochemistry section of pulmonary embolism after ex vivo preparation and staining for platelet CD41 (n = 6 per group, p < 0.05, Mann-Whitney U Test). Data are shown as mean ± s.e.m.

Inline graphic — (a) In vivo weighted MRI of the thorax after intravenous application of human thrombin (left panel) and injection of Control-MPIO (right panel, above) or LIBS-MPIO (right panel below). Right panel show extracted overlay of edema (gray zone) and MPIO-induced signal decay within this area (pseudo-colored pink-yellow). Below, 3D map of edema after thrombin and corresponding signal overlay after injection of LIBS-MPIO in the murine lung. (b) Edema area after thrombin injection in LIBS-MPIO or Control-MPIO group does not differ (6 mice per group, ns = not significant). (c) Percent change of signal intensity in human thrombin-induced edema after injection of LIBS-MPIO or Control-MPIO (n = 6 mice per group, p < 0.05, Mann-Whitney U Test). (d) Mean number of MPIO found per immunohistochemistry section of pulmonary embolism after ex vivo preparation and staining for platelet CD41 (n = 6 per group, p < 0.05, Mann-Whitney U Test). Data are shown as mean ± s.e.m.