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. 2016 May 3;6:25369. doi: 10.1038/srep25369

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(A) ROS1, ALK and c-MET expression in primary intra-hepatic cholangiocarcinoma (expression score: 0, 1+, 2+ and 3+). ROS1 and ALK are mainly localized in cytoplasm, and c-MET is localized in both cytoplasm and nucleus. (B) Break-apart Fluorescence in situ hybridization for ALK revealed wide-apart of the red and green signals (white arrows), indicating ALK translocation.