Table 2. Therapeutic efficacies stratified by RAM expression in IHCC.
| RAMhigh n = 18 | RAMlow n = 62 | p## | |
|---|---|---|---|
| Objective response rate | 22% (6–48) | 24% (14–37) | 1.000 |
| Disease control rate# | 39% (17–64) | 53% (40–66) | 0.423 |
| Median PFS (months) | 4.5 (1.8–8.5) | 5.9 (4.2‒7.1) | 0.533 |
| Median OS (months) | 5.7 (3.3–9.9) | 11.7 (8.8–14.5) | 0.021 |
RAM, ROS1/ALK/c-MET; IHCC, intrahepatic cholangiocarcinoma; PFS, progression - free survival; OS, overall survival.
#Disease control rate = complete response + partial response + stable disease >16 weeks.
##Objective response rates and disease control rates were compared using Fisher’s exact test, 2-tailed; PFS and OS were compared using log-rank tests.