Table 3. Univariate and multivariate analyses of factors associated with PFS and OS1.
Parameters | PFS |
OS |
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate2 | Multivariate3 |
Univariate2 | Multivariate3 |
|||||||||||
P value | Referent | HR | 95% CI | P value | P value | Referent | HR | 95% CI | P value | |||||
Age | – | Continuous Variable | 0.997 | 0.988 | – | 1.007 | 0.576 | – | Continuous Variable | 1.016 | 1.005 | – | 1.028 | 0.006 |
FIGO Stage | <0.001 | Advanced vs. Early | 2.413 | 1.577 | – | 3.691 | <0.001 | <0.001 | Advanced vs. Early | 3.618 | 1.728 | – | 7.576 | 0.001 |
Residual Disease | <0.001 | RD vs. R0 | 1.633 | 1.324 | – | 2.015 | <0.001 | <0.001 | RD vs. R0 | 1.958 | 1.457 | – | 2.631 | <0.001 |
ER | 0.036 | Negative | 1.302 | 1.077 | – | 1.573 | 0.006 | 0.150 | Negative | 1.288 | 1.014 | – | 1.636 | 0.038 |
PR | 0.009 | Negative | 0.718 | 0.538 | – | 0.958 | 0.024 | 0.061 | Negative | 0.911 | 0.617 | – | 1.346 | 0.641 |
AR | 0.368 | Negative | 0.982 | 0.813 | – | 1.185 | 0.847 | 0.023 | Negative | 0.744 | 0.578 | – | 0.959 | 0.022 |
FSHR | 0.975 | Negative | 1.024 | 0.862 | – | 1.217 | 0.786 | 0.586 | Negative | 1.166 | 0.936 | – | 1.451 | 0.171 |
LHR | 0.455 | Negative | 1.108 | 0.925 | – | 1.329 | 0.266 | 0.782 | Negative | 0.971 | 0.772 | – | 1.222 | 0.805 |
GnRHR | 0.800 | Negative | 0.907 | 0.691 | – | 1.192 | 0.484 | 0.488 | Negative | 0.976 | 0.693 | – | 1.374 | 0.889 |
HER2 | 0.746 | 0 | 0.916 | 0.576 | – | 1.457 | 0.710 | 0.815 | 0 | 0.747 | 0.407 | – | 1.373 | 0.348 |
Ki67 | 0.021 | Negative | 0.835 | 0.683 | – | 1.021 | 0.079 | 0.003 | Negative | 0.688 | 0.520 | – | 0.910 | 0.009 |
1Numbers of patients (number of events/patients at risk): PFS (549/749), OS (345/875).
2Log-rank tests.
3Cox regression analysis expressed as hazard ratios.