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. 2016 May 3;6:25342. doi: 10.1038/srep25342

Figure 4. Activation of AMPK enhanced the activity of the ERK1/2-RSK-nNOS pathway in the RVLM of rats with fructose-induced hypertension.

Figure 4

(A,B) Immunoblot showing the levels of P-ERK1/2T202/Y204, P-RSKT359/S363, P-eNOSS1177, P-nNOSS1416, and iNOS after treatment with resveratrol and compound C. (P-ERK1/2T202/Y204, P-RSKT359/S363, P-nNOSS1416, P-eNOSS1177, iNOS and actin the position of the 44/42, 90, 165, 140, 130 and 43-kDa molecular weight marker is indicated, respectively) The elevated ERK1/2, RSK, and nNOS phosphorylation ratios after treatment with resveratrol were reduced by compound C in the RVLM. The values shown are the means ± SEM, n = 6. *P < 0.05, **P < 0.01.