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. 2016 May 3;6:25342. doi: 10.1038/srep25342

Figure 5. The proposed mechanism by which the AMPK signaling pathway regulates blood pressure (BP) in the RVLM of rats with fructose-induced hypertension.

Figure 5

Treatments with an AMPK activator (resveratrol) and inhibitor (compound C) demonstrated that AMPK acts as an important regulator of BP through Rac1-NADPH oxidase activity. AMPK decreased blood pressure, abolished the generation of ROS and enhanced the activity of the ERK1/2-RSK-nNOS pathway by negatively regulating Racl-induced NADPH oxidase levels in the RVLM of rats with oxidative stress–induced hypertension.