Table 4.

Distributions and Parameter Values Used in PSA for Additional Parameters Added to the Model

Parameter	Explanation
gFOBT and colonoscopy uptake	Uncertainty on these calculated in PSA assuming ln(OR) distributed normally. The variance covariance matrices for the uptake regressions were not available to us, so we drew each coefficient independently and combined to create uptake probabilities.
Mortality rates	Adjusted for uncertainty by the underlying model.
Quality adjustment	Used β distribution with the mean and standard error values as reported in the UK EQ-5D norms.
Cost of reminders	As no data were given on the uncertainty, we assume a 10% standard error and used this to draw values from the appropriate γ distributions.
Impact of reminders on uptake	Reported mean and standard error values used to draw from the appropriate β distributions.

gFOBT, guaiac fecal occult blood test; OR, odds ratio; PSA, probabilistic sensitivity analysis.