Table 1.

Patient characteristics.^a

Study	Sample size	Subjects	Control group	Age
Gauthier et al.15	54 subjects 31 controls	Healthy elderly with asymptomatic WMH	Young healthy volunteers	Subjects: 63 ± 5 Controls: 24 ± 3
Richiardi et al.16	20 AD 15 MCI 28 controls	AD and MCI	Healthy elderly	AD: 76 ± 7 MCI: 71 ± 10 Controls 73 ± 7
Conijn et al.17	49	Patients with history of vascular events or cardiovascular risk factors	None	58.9 ± 10
Yezhuvath et al.18	Subjects: 12 Controls: 13	AD	Healthy elderly	Subjects: 70.5 ± 8.3 Controls: 68.7 ± 8.4
Hund-Georgiadis et al.19	Subjects: 5 Young Controls: 6 Older Controls: 6	Stroke and ‘cerebral microangiopathy’ (white matter MRI signal changes.)	Young healthy volunteers and older healthy volunteers	Subjects: 61.8 (54–67) Young controls: 24.8 (23–27) Older controls: 57 (51–63)

AD: Alzheimer’s disease, MCI: mild cognitive impairment.

^aPatient characteristics of included studies of CVR in cerebral SVD.