A–D refer to epileptic (Patient 5, A, B; Patient 10, C; Patient 8, D; all stained with AT8), E Control (Patient 31, CP13), and F, CTE (Patient 23, CP-13) brain specimens. Note the widespread filamentous, beaded neurites and axons indicated by arrows and arrowheads in both epileptic and CTE brain. F shows the uncommon appearance of cellular debris in a control brain from a 96 year old post mortem sample.