Table 3.
Significantly associated CFH risk and protective haplotypes
| Haplotype | Risk/protective | SNP variant |
Odds ratio heterozygous/ homozygous |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | |||
| H1 | Risk | C | C | G | T | C | T | A | G | 2.46/3.51 |
| H2 | Protective | C | T | A | T | T | G | A | G | 0.54/0.27 |
| H3 | Neutral | T | C | G | T | T | G | G | T | NS |
| H4 | Protective | C | C | G | C | T | G | A | G | 0.48 |
| H5 | Neutral | T | C | G | T | T | G | A | G | NS |
SNP variant: 1 = rs3753394 (−257), promoter 2 = rs529825 (IVS1), 3 = rs800292 (I62V), 4 = rs3766404 (IVS6), 5 = rs1061170 (Y402H), 6 = rs203674 (IVS10), 7 = rs3753396 (Q672Q), 8 = rs1065489 (D936E). CFH, factor H gene; NS, non significant; SNP, single nucleotide polymorphism.