TABLE 2.

Biochemical Constituents of Drusen

α1-Antitrypsin

Alzheimer amyloid β peptide

Amyloid P component

Apolipoproteins B and E

Cholesterol esters

Clusterin

Complement factors (Clq, C4, C5)

Complement receptor 1

Factor X

Glycoprotein moieties recognized by various lectins

Heparan sulfate proteoglycan

Human leukocyte antigen DR

Immunoglobulins

MHC class II antigens

Peroxidized lip derived material

Phospholipids

Tissue inhibitor of matrix metalloproteinases-3

Transthyretin

Ubiquitin

Vitronectin

modified from Zarbin.¹⁵⁹