Table 1.
Donor tissue and fixation information
| Age (years) | Cause of death | Post mortem delay |
Initial fixative | Time until Karnovsky’s fixative |
Ophthalmic history |
|---|---|---|---|---|---|
| Rhesus macaque (Macaca mulatta) | |||||
| 17 | Euthanasia | 15 min | Karnovsky’s | – | – |
| Human normal controls | |||||
| 1 | Unknown | 37 h | 2% PFA | 22 months | None reported |
| 10 | Unknown | 25 h | 2% PFA | 18 months | None reported |
| 18 | Cardiac arrest | 13 h | 2% PFA | 2 months | None reported |
| 19 | Motorbike accident | 18 h | 2% PFA | 2 months | None reported |
| 24 | Intracranial haemorrhage | 55 h | Karnovsky’s | – | None reported |
| 34* | Lung cancer | 8 h* | 2% PFA | 3 weeks | None reported |
| 42 | Hanging suicide | 20 h | 2% PFA | 16 months | None reported |
| 43 | Prescription drug overdose | 17 h | 2% PFA | 19 months | None reported |
| 47 | Rectal carcinoma | 8h | 2% PFA | 19 months | None reported |
| 55 | Surgical enucleation | <30 min | Tannic acid–glutaraldehyde | – | Extra ocular tumour |
| 63* | Prostate cancer | 8 h* | 2% PFA | 4 months | None reported |
| 71 | Throat cancer | 11 h | 2% PFA | 4 months | None reported |
| 73 | Cholangiocarcinoma | 7h | 2% PFA | 19 months | None reported |
| 74 | Lung cancer | 14 h | 2% PFA | 3 months | None reported |
| 75 | Unknown | 4h | Karnovsky’s | – | Healthy eye from a unilateral Coats’ disease case |
| 79 | Lung cancer | 13 h | 2% PFA | 19 months | None reported |
| 80 | Chronic obstructive pulmonary disease type II | 13 h | 2% PFA | 19 months | None reported |
| 84 | Lung cancer | 9h | 2% PFA | 19 months | None reported |
| 96 | Unknown | 47 h | 2% PFA | 3 months | None reported |
| 97 | Unknown | 48 h | 2% PFA | 3 months | None reported |
| Type 2 diabetes | |||||
| 74 | Intracranial haemorrhage | 7h | 2% PFA | 13 months | None reported |
| 77 | Pancreatic cancer | 8h | 2% PFA | 3 months | None reported |
| 78 | Stroke | 9h | 2% PFA | 15 months | None reported |
| 79 | Cardiac arrest | 9h | 2% PFA | 14 months | None reported |
| Diabetic retinopathy | |||||
| 71 | Cerebrovascular accident | <12 h | 2% PFA | 6 months | Diabetic retinopathy, laser surgery |
| MacTel type 2 and type 2 diabetes | |||||
| 75 | Unknown | 4h | Karnovsky’s | – | MacTel type 2, no retinopathy |
| Post mortem degradation controls | |||||
| 34* | Lung cancer | 56 h* | 2% PFA | 3 weeks | None reported |
| 63* | Prostate cancer | 56 h* | 2% PFA | 4 months | None reported |
‘Time until Karnovsky’s fixative’ refers to the time between initial fixation of the tissue and its transfer into Karnovsky’s fixative.
*
Indicates the normal controls from which the other donor eye was used as a post mortem degradation control.