Table 1.

Genotyping and Association Analysis of the TLR3 rs3775291 Variant in Eight Cohorts.^*

Value	Columbia Series		Iowa Series		Amsterdam Series		Rotterdam Series		Germany Series		Iceland Series		AREDS Series		Australia Series		Total
	Patients with Geographic Atrophy	Controls	Patients with Geographic Atrophy	Controls	Patients with Geographic Atrophy	Controls	Patients with Geographic Atrophy	Controls	Patients with Geographic Atrophy	Controls	Patients with Geographic Atrophy	Controls	Patients with Geographic Atrophy	Controls	Patients with Geographic Atrophy	Controls	Patients with Geographic Atrophy	Controls
Total no. of subjects	211	365	102	295	89	264	64	843	184	366	210	169	163	204	57	163	1080	2669
Genotype (no. of subjects)
CC	105	204	53	152	41	136	28	422	105	191	102	90	82	101	30	70	546	1366
CT	93	133	37	108	40	103	29	341	63	139	96	65	71	82	21	76	450	1047
TT	13	28	12	35	8	25	7	80	16	36	12	14	10	21	6	17	84	256
Minor-allele (T allele) frequency	0.28	0.26	0.30	0.30	0.31	0.29	0.33	0.30	0.26	0.29	0.29	0.28	0.28	0.30	0.29	0.33	0.29	0.29
P value
Hardy–Weinberg equilibrium	0.54	0.58	0.36	0.09	0.89	0.67	1.00	0.63	0.33	0.33	0.24	0.93	0.56	0.80	0.82	0.82
For difference in allele     frequency	0.44		0.94		0.53		0.36		0.29		0.75		0.46		0.35		0.59
Odds ratio (95% CI)†	1.12 (0.86–1.47)		0.99 (0.70–1.40)		1.12 (0.78–1.63)		1.20 (0.82–1.75)		0.86 (0.65–1.14)		1.05 (0.77–1.45)		0.89 (0.64–1.22)		0.8 (0.5–1.27)		1.03 (0.92–1.15)

^*AREDS denotes Age-Related Eye Disease Study, and CI confidence interval.

^†Odds ratios are for the frequency of the TLR3 variant in the geographic atrophy group as compared with the control group.