Table 1.
Demographic information and disease history of patients (left) and age-matched control subjects (two rightmost columns).
| ID | Age | Gender | LED | PD Dur | DBS Dur | Pre-op UPDRS | Post-op UPDRS | Asymmetry | Therap. Stim Right | Therap. Stim Left | veR Volt | veL Volt | CO Age | Gender | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dopa OFF | Dopa ON | DBS OFF | DBS ON | Rec. in Dopa OFF | |||||||||||||
| 1 | 32 | M | 631 | 2.0 | 0.8 | 44.0 | 25.0 | 13.0 | 6.0 | No cond | 73.3 | −10/+11, 60, 130, 2.5 V | −2/+C, 60, 130, 2.3 V | 2.8 | 1.5 | 30 | m |
| 2 | 42 | M | 567 | 7.5 | 2.1 | 40.0 | 24.0 | 47.0 | 21.5 | No cond | 54.9 | −9/−10/+C, 60, 180, 2.0 V | −1/−2/+C, 60, 180, 2.1 V | N/A | N/A | 40 | m |
| 3 | 45 | M | 1249 | 7.5 | 0.3 | N/A | N/A | 39.5 | 10.0 | No cond | 61.4 | −10/+C, 60, 130, 2.7 V | −2/+C, 60, 130, 2.3 V | 2.6 | 4.0 | 51 | f |
| 4 | 48 | F | 1082 | 12.0 | 0.8 | 34.0 | 19.0 | 34.0 | 14.0 | No cond | 66.7 | −9/+C, 60, 130, 3.8 V | −2/+C, 60, 130, 2.8 V | 2.4 | 2.0 | 51 | m |
| 5 | 49 | M | 809 | 9.0 | 2.3 | 26.0 | 7.0 | 32.0 | 7.5 | veR, veL | 77.8 | −10/+C, 60, 90, 3.2 V | −2/+C, 60, 90, 2.0 V | 2.4 | 5.0 | 53 | f |
| 6 | 53 | M | 624 | 0.0 | 0.3 | 50.0 | 17.0 | 48.0 | 35.0 | veR, veL | 53.1 | −10/+C, 60, 130, 2.7 V | −2/+C, 60, 130, 2.7 V | 1.4 | 2.8 | 53 | m |
| 7 | 58 | F | 1341 | 12.0 | 2.0 | 67.0 | 10.0 | 14.5 | 14.5 | No cond | 93.8 | −10/+C, 60, 150, 2.6 V | −2/+C, 60, 150, 2.5 V | 0.8 | 1.6 | 54 | m |
| 8 | 58 | M | 1203 | 20.5 | 3.0 | 54.0 | 10.0 | 22.5 | 18.5 | No cond | 45.2 | −9/−10/+C, 60, 130, 3.0 V | −1/−2/+C, 60, 130, 3.3 V | 3.4 | 4.3 | 54 | f |
| 9 | 60 | M | 1027 | 19.8 | 3.8 | 57.0 | 17.0 | 45.5 | 24.5 | All cond | 60.9 | −8/+C, 60, 160, 2.0 V | −1/+C, 60, 160, 2.4 V | 2.5 | 2.9 | 56 | f |
| 10 | 60 | F | 967 | 22.5 | 5.8 | N/A | N/A | 46.5 | 46.5 | All cond | 47.2 | −10/+C, 90, 130, 3.9 V | −1/+C, 60, 130, 3.6 V | N/A | N/A | 56 | m |
| 11 | 60 | F | 1038 | 8.5 | 1.8 | 39.0 | 6.0 | 42.0 | 42.0 | No cond | 65.4 | −10/+9, 90, 130, 3.2 V | −2/+C, 60, 130, 2.0 V | 2.8 | 1.4 | 57 | f |
| 12 | 60 | M | 550 | 10.0 | 3.2 | N/A | N/A | 55.0 | 27.0 | veR, veL | 55.3 | −9/+C, 60, 180, 4.0 V | −1/+C, 60, 180, 4.5 V | 3.2 | 2.4 | 61 | m |
| 13 | 62 | M | 926 | 11.5 | 1.3 | 51.0 | 44.0 | 52.0 | 23.0 | No cond | 53.9 | −10/+C, 60, 160, 3.7 V | −2/+C, 60, 160, 3.5 V | 1.6 | 3.2 | 63 | m |
| 14 | 65 | M | 566 | 16.7 | 3.0 | 15.0 | 9.0 | 25.0 | 9.5 | No cond | 75.6 | −10/−9/+C, 60, 130, 3.9 V | −1/+C, 60, 130, 1.5 V | 3.2 | 3.2 | 68 | f |
| 15 | 69 | F | 508 | 15.2 | 0.8 | 31.0 | 17.0 | 26.0 | 23.5 | No cond | 89.5 | −10/+9, 60, 180, 2.5 V | −2/+C, 60, 180, 2.8 V | N/A | N/A | 68 | f |
| 16 | 72 | m | 1111 | 12.2 | 2.0 | 29.0 | 11.0 | 27.5 | 15.5 | No cond | 64.3 | −10/+9, 60, 130, 4.0 V | −2/+1, 60, 130, 3.5 V | 3.6 | 4.0 | 76 | f |
| 17 | 73 | m | 537 | 20.5 | 7.5 | 31.0 | 12.0 | 31.0 | 24.0 | No cond | 63.0 | −10/+C, 60, 130, 3.1 V | −2/+C, 60, 130, 3.1 V | 4.0 | 5.6 | 76 | m |
LED = Levodopa equivalent daily dose (conversion factors after Tomlinson et al. (2010); PD Dur = Disease duration in years past diagnosis; DBS Dur = DBS Duration (years past electrode implantation); UPDRS = UPDRS-III score; Dopa = Dopaminergic medication; Rec. in Dopa OFF = Conditions recorded in Dopa OFF; Asymmetry = Symptom severity of the left side relative to severity on both sides (UPDRS-III 20−26 left-sided items/[left-sided items + right-sided items] * 100), Therap. Stim Right/Left = Therapeutic stimulation settings of the right or left electrode (Negative poles/positive pole [C = case, 0 and 8 are the ventralmost contacts for the left and right electrode respectively], pulse width (μs), frequency (Hz), intensity (V)), veR Volt = Voltage during unilateral ventral right stimulation; veL Volt = Voltage during unilateral ventral left stimulation; CO = Control subjects.