Table 4.

Schedule of study visits and assessments

	Screen	Visit 1	Visit 2 6-month	Visit 3 12-month	Visit 4 18-month	Visit 5 24-month
Visit Visit schedule	Week -4-0	Baseline Week 0	Weeks 22–30	Weeks 48–56	Weeks 74–82	Weeks 100–108
Informed consent/assent	✓ or	✓
Inclusion/exclusion criteria	✓ or	✓
Demographics		✓
Family medical and psychiatric history		✓
Child medical and psychiatric history		✓
Developmental history		✓
Medication history and current medications		✓
Psychiatric medication (s) Prescribed or continued at visit (including drug and dose and concordance)		✓	✓	✓	✓	✓
Other medication since last visit			✓	✓	✓	✓
Learning difficulties		✓
Cardiac examination		✓
Vital signs		✓	✓	✓	✓	✓
Height		✓	✓	✓	✓	✓
Weight		✓	✓	✓	✓	✓
BMI		✓	✓	✓	✓	✓
Parental height		✓
Target height		✓
Calculation of predictive definitive height value (Tanner-Whitehouse method)		✓
Pubertal maturation		✓	✓	✓	✓	✓
SNAP-IV		✓	✓	✓		✓
CGI-S		✓	✓	✓		✓
CGI-I			✓	✓		✓
CGAS		✓	✓	✓		✓
DCDQ'07		✓				✓
SCQ		✓				✓
SDQ		✓	✓	✓		✓
AIMS		✓	✓	✓		✓
CSHQ		✓	✓	✓		✓
MFQ-P (parent version)		✓	✓	✓		✓
MFQ-C (self-report version) ages≥8 years		✓	✓	✓		✓
PLikS		✓	✓	✓		✓
DAWBA Tics		✓	✓	✓		✓
YGTSS		✓	✓	✓		✓
DAWBA rapidly changing mood (parent version)		✓	✓	✓		✓
DAWBA rapidly changing mood (child version)		✓	✓	✓		✓
DAWBA awkward and troublesome behaviour		✓	✓	✓		✓
C-SSRS (baseline)		✓
C-SSRS (since last seen)			✓	✓		✓
Substance use questionnaire		✓	✓	✓		✓

AIMS, Abnormal Involuntary Movement Scale; BMI, body mass index; CGAS, Children's Global Assessment; CGI, Clinical Global Impressions; CSHQ, Child's Sleep Habits Questionnaire; C-SSRS, Columbia-Suicide Severity Rating Scale; DAWBA, Development and Wellbeing Assessment; DCDQ'07, Developmental Coordination Disorder Questionnaire '07; MFQ, Mood and Feelings Questionnaire; PLikS, Psychosis Like Symptoms; SCQ, Social Communication Questionnaire; SDQ, Strength and Difficulties Questionnaire; SNAP-IV, Swanson Nolan and Pelham IV rating scale; YGTSS, Yale Global Tic Severity Scale.