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. 2016 Apr 29;6(4):e009537. doi: 10.1136/bmjopen-2015-009537

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Domains and missense mutations found in HUWE1 with the relative boundaries of each domain indicated. The known missense alterations are shown below the DUF4414 and HECT domains. The p.G4310R mutation reported in this paper is in red. The WWE domain is named for its conserved residues and is predicted to mediate specific protein–protein interactions in ubiquitin and ADP-ribose conjugation systems. The C-terminal catalytic HECT belongs to a subclass of ubiquitin-protein E3 ligases. DUF913 belongs to a family found in various ubiquitin protein ligases and DUF4414 is in a family of domains frequently found in DNA-binding proteins of the URE-B1 type. DUF, domains of unknown function.