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Concepts for microbial surveillance and standardization in laboratory animals. (a) Traditional and current focus of health monitoring is based on virulence of microorganisms (symbiotic, opportunistic, pathogenic) and aims to exclude or report pathogens (and potential pathogens), depending on the barrier level and specified excluded agents. (b) Microbial relevance (other than pathogenicity) to the host is increasingly recognized, as is the complexity and diversity of the microbiota.
