Table 1.
Previously published variants associated with circulating leukocyte telomere length
| SNP | Position (GRCh37/hg19) | Nearby gene | Short allele | Long allelea | MAF | Published βb | Published P-value | Reference |
|---|---|---|---|---|---|---|---|---|
| rs10936599 | chr3:169492101 | TERC | T | C | 0.25 | 0.117 | 2.5 × 10−31 | Codd et al. (9) |
| rs2736100 | chr5:1286516 | TERT | A | C | 0.49 | 0.094 | 4.4 × 10−19 | Codd et al. (9) |
| rs7675998 | chr4:164007820 | NAF1 | A | G | 0.22 | 0.090 | 4.3 × 10−16 | Codd et al. (9) |
| rs9420907 | chr10:105676465 | OBFC1 | A | C | 0.14 | 0.083 | 6.9 × 10−11 | Codd et al. (9) |
| rs8105767 | chr19:22215441 | ZNF208 | A | G | 0.30 | 0.058 | 1.1 × 10−9 | Codd et al. (9) |
| rs755017 | chr20:62421622 | RTEL1 | A | G | 0.12 | 0.074 | 6.7 × 10−9 | Codd et al. (9) |
| rs11125529 | chr2:54475866 | ACYP2 | C | A | 0.14 | 0.067 | 4.5 × 10−8 | Codd et al. (9) |
| rs6772228 | chr3:58376019 | PXK | A | T | 0.05 | 0.120 | 3.9 × 10−10 | Pooley et al. (10) |
| rs3027234 | chr17:8136092 | CTC1 | T | C | 0.23 | 0.057 | 2.3 × 10−8 | Mangino et al. (11) |
MAF, minor allele frequency.
aLong allele is allele associated with longer telomere length.
bβ-estimate is reported in telomere kb per long allele.