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The CRISPR-Cas9 system induced anti-growth effects in HPV6/11 E 7-transfromed keratinocytes. Obvious difference between the control group and the CRISPR-Cas9 group was observed in HPV6 E 7-transformed keratinocytes (a) (P < 0.001, ANOVA) and HPV 11 E 7-transformed keratinocytes (b) (P < 0.001, ANOVA). Such difference was not observed in keratinocytes transfected with pcDNA3.1(+) empty vector (c) (P > 0.05, ANOVA). Results were shown as mean ± s.d.
