Table 3.
The presence of intervillous neutrophil extracellular traps (NETs) versus no NETs in all cases corresponds to vascular pathology and inflammation*
| Variables | No NETs (median; IQR) |
NETs (median; IQR) |
p Value |
|---|---|---|---|
| Inflammation | |||
| Maternal | |||
| Chronic | 8 (26) | 16.5 (6.5) | NS |
| Acute | 4 (14) | 19 (14) | 0.06559 |
| Fetal | |||
| Chronic | 9.5 (23) | 10 (16) | NS |
| Acute | 9 (20.75) | 32 (0) | NS |
| Circulatory | |||
| Decidual vasculopathy | |||
| Perivasculitis; mild | 4 (26) | 14 (10.25) | NS |
| Vasculitis severe; fibrinoid necrosis | 4.5 (14.75) | 23 (39) | 0.02286 |
| Maternal thrombosis: occlusive | 10.5 (24) | 4 (13) | NS |
| Maternal; non-occlusive | 9 (25) | 11 (0) | NS |
| Laminar decidual necrosis (>10%) | 4.5 (14.75) | 23 (31) | 0.03458 |
| Infarct | |||
| Fetal: focal villous infarction | 8 (26) | 11.5 (10.5) | NS |
| Fetal: multifocal villous infarction | 6.5 (14.75) | 23 (12) | NS |
| Maternal–fetal interface haemorrhage† | 4.5 (13.75) | 29 (40) | 0.02116 |
| Fetal vasculopathy | |||
| Distal villous lesions | 19 (19.75) | 13.5 (31.75) | NS |
| Large vessel lesions | 15 (19) | 13 (30.5) | NS |
| Choriangiosis | 24.5 (17.25) | 13.5 (32) | NS |
| Fetal thrombotic vasculopathy | |||
| Occlusive | 9 (16.25) | 45 (26.5) | NS |
| Non-occlusive | 4 (13.25) | 29 (23) | 0.003374 |
*Comparison between groups tested by Kruskal–Wallis.
†Acute and chronic haemorrhage are not presented, but were NS separately likely due to small numbers.