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. 2016 Apr 27;9:2511–2518. doi: 10.2147/OTT.S102422

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© 2016 Zhou et al. This work is published and licensed by Dove Medical Press Limited

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HIF-1α is involved in the prevention of hypoxia-induced EMT by PF.

Notes: MDA-MB-231 cells grown under normoxia and hypoxia were treated with 25 μM PF for 24 hours. (A) PF inhibited the hypoxia-induced expression of HIF-1α. (B) Knockdown of HIF-1α inhibited hypoxia-induced HIF-1α expression. (C) Knockdown of HIF-1α restored hypoxia-induced reduction of E-cadherin expression. Each bar represents the mean ± SD. The results were reproduced in three independent experiments. *P<0.05 vs normoxia group, ^#P<0.05 vs hypoxia group.

Abbreviations: PF, paeoniflorin; EMT, epithelial–mesenchymal transition; SD, standard deviation.