Table 6.
Results of meta-analysis for diagnostic value of BRAFV600E mutation in indeterminate cases
| Parameter | Indeterminate
|
SMC
|
AUS/FLUS
|
FN/SFN
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Result | 95% CI | Heterogeneity, I2 | Result | 95% CI | Heterogeneity, I2 | Result | 95% CI | Heterogeneity, I2 | Result | 95% CI | Heterogeneity, I2 | |
| Pooled sensitivity | 0.442 | 0.416–0.468 | 86.4% | 0.594 | 0.556–0.631 | 76% | 0.401 | 0.328–0.477 | 77.4% | 0.195 | 0.128–0.278 | 73.1% |
| Pooled specificity | 0.997 | 0.994–0.999 | 0 | 0.861 | 0.784–0.918 | 70.8% | 0.995 | 0.982–0.999 | 17.9% | 0.997 | 0.983–1.000 | 11.8% |
| Pooled LR, + | 12.267 | 8.175–18.406 | 0 | 3.434 | 1.625–7.259 | 64.1% | 7.001 | 3.336–14.691 | 0 | 9.573 | 3.611–25.379 | 0 |
| Pooled LR, − | 0.613 | 0.551–0.683 | 84.8% | 0.542 | 0.462–0.637 | 29.8% | 0.694 | 0.576–0.835 | 56.1% | 0.733 | 0.522–1.030 | 85% |
| Pooled DOR SROC | 23.939 | 15.388–37.242 | 0 | 7.588 | 3.944–14.598 | 0 | 14.469 | 6.100–34.320 | 0 | 14.808 | 4.966–44.156 | 2.2% |
| AUC | 0.8711 | 0.7674 | 0.7999 | – | ||||||||
| Q* | 0.8015 | 0.7079 | 0.7358 | – | ||||||||
Note:
*
The Q index indicates the point at which sensitivity is equal to specificity. “–’’ indicates the AUC of the SROC was not significant in FN/SFN cases, since the lower limit of the AUC was less than 0.5.
Abbreviations: FNA, fine-needle aspiration; CI, confidence interval; LR, likelihood ratio; DOR, diagnostic odds ratio; SROC, summary receiver-operating characteristic; AUC, area under the curve.