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. 2016 Mar 17;1(3):e80749. doi: 10.1172/jci.insight.80749

Figure 5. Effect of trimeprazine on WT, Irs2–/–, or Pdx1+/– mice treated with i.p. injections of 10 mg/kg trimeprazine or without (saline) once a day for 3 weeks.

Figure 5

(A) IPGTT in C57BL/6 mice treated between 5.5 and 8.5 weeks of age. The mean ± SEM is shown for each data point. (B) AUC (from A) was calculated (Medcalc, version 13.3.3) and analyzed by a GLM (SPSS, version 23), with genotype and drug treatment as interacting factors. Bonferroni-corrected P values of less than 0.05 were considered significant. (C) HOMA2 %B was calculated using fasting glucose and insulin concentrations determined with the indicated experimental mice. Data were analyzed by a GLM, with genotype and drug treatment as interacting factors. Bonferroni-corrected P values are shown; a P value of less than 0.05 was considered statistically significant. Sal, saline; Trimep, trimeprazine.