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. 2016 Apr 26;72(Pt 5):682–693. doi: 10.1107/S2059798316004502

Figure 2.

Figure 2

Structure of ERK5 in complex with XMD8-92 (compound 2). ERK5 is shown in ribbon representation with the hinge region, P-loop, αC helix and activation loop coloured yellow, blue, coral and magenta, respectively. The central portion of the activation loop (amino acids 208–215) is missing from the model. XMD8-92 (compound 2) binds in the ATP-binding site and is shown as a stick model with C atoms in green. The 2mF o − DF c OMIT electron density for compound 2 is shown as a lilac mesh contoured at 1.0σ.