Fig 3. Central (0.3 μg, icv) administration of NMU reduces amphetamine-induced locomotor stimulation in mice.

Amphetamine-induced (2 mg/kg, ip) locomotor stimulation was reduced, but not blocked, by a central injection of a lower does of NMU (0.3 μg, icv). Central administration of this lower dose of NMU had no effect per se on locomotor activity. Data are presented as mean ± SEM (n.s. P>0.05, *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001 compared to vehicle-vehicle treatment).