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. 2016 May 3;11(5):e0152090. doi: 10.1371/journal.pone.0152090

Fig 1. MiR-122 is down-regulated in hepatocellular carcinoma cell lines, and associated with doxorubicin resistance.

Fig 1

(A) The expression of miR-122 was down-regulated in HCC cell lines compared with the normal hepatocytes. *p<0.05 vs. L-O2 cells, t test. (B) The cell viability of Huh7, Hep3B, HepG2, and PLC was measured by MTT assay after they were treated with 0.2 μg/ml doxorubicin or 1.0 μg/ml doxorubicin for 48 h. *p<0.05 vs. Huh7 cells, t test. (C) MiR-122 expression was further down-regulated in Huh7/R cells compared with its parental Huh7 cells. *p<0.05, t test.