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. 2016 May 3;11(5):e0152090. doi: 10.1371/journal.pone.0152090

Fig 2. Overexpression of miR-122 resensitizes Huh7/R cells to DOX.

Fig 2

(A) Huh7 and Huh7/R cells were treated with different concentrations of doxorubicin for 48 h, and cell viability was determined by MTT assay. The IC50 was determined according to the survival curves. *p<0.05, t test. (B) Huh7 cells were transfected with miR-122 inhibitors or NCO for 24 h followed by the treatment of DOX at different concentrations for another 48 h followed by cell viability analysis. The IC50 was determined according to the survival curves. *p<0.05, t test. (C) Huh7/R cells were transfected with miR-122 mimics or NCO for 24 h followed by the treatment of DOX at different concentrations for another 48 h followed by cell viability analysis. The IC50 was determined according to the survival curves. *p<0.05, t test.