Figure 7. A high proportion of the cAMP interactome are somatic SNV mutations in human osteosarcoma.
(A) Analysis of functional pathways within the somatic SNV mutations of human OS using Cytoscape. Brown color indicates a cAMP related pathway, blue color indicates non cAMP related pathways. (B) Analysis of the enrichment for somatic SNV mutations within the cAMP interactome in each of the indicated tumor types. Based on somatic SNV mutations identified by whole genome sequencing. P value defined using hypergeometric distribution test. (C) Graphical summary of the differences between primary osteoblasts and OS subtypes regarding cAMP and CREB1 function. See also Figure 7—figure supplement 1.
Figure 7—figure supplement 1. Analysis of cAMP and cGMP pathway enrichment of somatic SNV tumor mutations.
Table comparing the enrichment of somatic SNV tumor mutations within OS, Ewings and Breast cancer in the cAMP pathway, cGMP pathway and those unique to the cAMP and cGMP pathway respectively.