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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Clin Cancer Res. 2016 Jan 5;22(9):2250–2260. doi: 10.1158/1078-0432.CCR-15-2276

Figure 4. Intermittent, longer-term PI3K inhibition increases tumor cell apoptosis and suppresses proliferation in combination with anti-estrogen therapy.

Figure 4

Mice were pretreated with fulv 3 d before treatment with one or two doses of GDC-0941 as indicated. Tumors were harvested at 0–48 h after GDC-0941 treatment, and analyzed by (A) TUNEL to assess apoptosis, or (B) IHC for geminin and Ki67 to assess cell proliferation. Geminin:Ki67 ratios were calculated. Data are shown as mean of triplicate tumors + SD. *p≤0.05 compared to baseline controls. #p≤0.05 by Bonferonni post-hoc test as indicated with brackets.