Fig. 3.

BDNF (10 ng/mL) increases the frequency, but not the amplitude, of spontaneous miniature inhibitory postsynaptic currents (mIPSCs). The mIPSCs were recorded in the same conditions as described for Fig. 2. a The upper panel represents mIPSC tracings recorded in the absence (upper trace) and presence (lower trace) of BDNF (10 ng/mL). b Representative average tracings of mIPSCs of two superimposed events in the absence (1) and presence (2) of BDNF (10 ng/mL), from the same cell. c, e Time course changes in mIPSC frequency (c) and amplitude (e) induced by application of BDNF (n = 9). d, f Averages of the absolute values of frequency (d) or amplitude (f) are shown as individual data points in the absence (−) of BDNF and after (+) BDNF administration (n = 9). g, h Averages of the absolute values of rise (g) or decay (h) times are shown as individual data obtained in the absence (−) of BDNF and after (+) BDNF administration (n = 9). Values are mean ± SEM. **p < 0.01 and n.s. p > 0.05 (two-tailed paired Student’s t test