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Functional domains of PKD-1. PKD-1 contains multiple functional domains including alanine and proline rich domain (APR); cysteine-rich, zinc finger-like domains (CR1 and CR2); acidic-rich region (AR); and pleckstrin homology domains (PH). There are six conserved phosphorylation sites. In response to a variety of biological factors, these sites can be phosphorylated to activate PKD-1 and regulate fundamental cellular functions.
