Table 1.
Atp1a2 gene modified mouse models.
| Mouse model* | Atp1a2 genetic alteration | Major behavioral observations | References |
|---|---|---|---|
| α2+/KOE4 | Deletion targeting exon 4 | - Enhanced fear and anxiety - Hypoactivity - Impaired spatial learning |
James et al., 1999; Lingrel et al., 2007; Moseley et al., 2007 |
| α2+/KOE21 | Deletion targeting exon 21 | - Enhanced fear and anxiety | Ikeda et al., 2003 |
| α2+/KOE2 | Deletion targeting exon 2 | - Not assessed | Ikeda et al., 2004 |
| α2+/W887R | Single nucleotide substitution (T2763C) causing a single amino acid substitution (W887R) | - Enhanced fear and anxiety | Leo et al., 2011 |
| α2+/G301R | Single nucleotide substitution (G901A) causing a single amino acid substitution (G301R). | - Hypoactivity (females only) - Compulsive behaviors (females only) - Stress-induced depression |
Bøttger et al., 2016 |
*
Three Atp1a2 knock-out (KO) and two knock-in (KI) mice have been described. For all five models, only heterozygous animals are viable after birth. No models of conditional Atp1a2 KO in CNS related cells have been reported.