Table 1.

Body weights and serum urea and creatinine levels in mice fed control (CON) or 40% calorie‐restricted diets (CRL, CRS and CRF) after 6 and 18 months of dietary intervention. Data are expressed as mean values ± SE

	CON		CRL		CRS		CRF
	6 months	18 months	6 months	18 months	6 months	18 months	6 months	18 months
Weight (g)	37.70 ± 1.33a	32.56 ± 2.58	26.71 ± 0.78	28.19 ± 0.75	26.73 ± 1.1b	28.86 ± 1.53	28.02 ± 1.19	28.67 ± 0.94
Serum urea (mg dL−1)	39.63 ± 1.43c	36.24 ± 2.14c	31.73 ± 1.19	32.96 ± 3.87	31.8 ± 1.85	29.32 ± 1.82	28.73 ± 2.64	31.85 ± 1.77
Serum creatinine (mg dL−1)	0.68 ± 0.06	0.61 ± 0.12	0.85 ± 0.08d	0.54 ± 0.07	0.61 ± 0.07	0.61 ± 0.06	0.50 ± 0.09	0.63 ± 0.07

^a P < 0.05 vs CON 18 months and P < 0.01 vs CRS 6 months.

^b P < 0.05 vs CRS 18 months.

^c P < 0.01 vs CRS 6 months.

^d P < 0.01 vs CRL 18 months and P < 0.05 vs CRS and CRF 6 months.