Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Feb;13(2):183–196. doi: 10.11909/j.issn.1671-5411.2016.02.003

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Institute of Geriatric Cardiology

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.

PMC Copyright notice

Figure 1. — The steroidal androgens, testosterone and DHT, mediate their biological effects predominantly through genomic pathway by binding to the AR and translocation into the nucleus, thereby facilitating the ability of AR to bind to its cognate response element, and recruiting coregulators to regulate the expression of target genes (left side). The nongenomic stimulation of second messenger cascades by androgens exerts biological effects through modulation of the transcriptional activity of AR or other transcription factors (right side). AR: androgen receptor; ARA: androgen receptor activator; ARE: androgen response element; cAMP: cyclic adenosine monophosphate; DHT: dihydrotestosterone; GPCR: G-protein coupled receptor; HSP: heat shock protein; MAPKs: mitogen-activated protein kinases; PKA: protein kinase A; PKC: protein kinase C; SHBG: steroid hormone binding globulin; SHBGR: SHBG receptor; Src: tyrosine kinase C; SHC: Src homology 2 domain-containing.