Figure 2.

NMDA-R-deficient iMSNs are smaller due to reduced dendritic arborization. A, Representative maximal intensity projections of deconvoluted Z-stack obtained from biocytin-filled control (Ctrl) and cKO iMSNs. Scale bar, 20 μm. B, 3D Sholl analysis of reconstructed neurons showed a reduced dendritic arborization for cKO mice. C, Dendrite number in function of branch order is reduced in cKO iMSNs. D, Dendritic branch length in function of dendrite order is not different between the two groups. E, Whole-cell current-clamp recordings showed a smaller membrane capacitance for cKO iMSNs, indicating a smaller surface area.