Table 2.
Diagnostic performance of AST/ALT, MCV, GGT, ANI, and ANI combined with GGT for diagnosis of ALD
| Variable | AST/ALT | MCV | GGT | ANI | ANI + GGT |
|---|---|---|---|---|---|
| AUROC (95%CI) | 0.826 (0.752–0.885)a | 0.814 (0.739–0.875) | 0.815 (0.740–0.876) | 0.935 (0.879–0.969)b | 0.976 (0.934–0.994)c |
| Cut-off | 0.95 | 94.0 fl | 87.0 IU/L | –0.22 | NA |
| Sensitivity, % | 75.29 | 72.94 | 80.23 | 87.21 | 89.53 |
| Specificity, % | 94.34 | 83.02 | 79.25 | 92.45 | 96.23 |
| PPV, % | 95.5 | 87.3 | 86.2 | 94.9 | 97.5 |
| NPV, % | 70.4 | 65.7 | 71.2 | 81.7 | 85.0 |
| PLR | 13.30 | 4.30 | 3.87 | 11.54 | 23.73 |
| NLR | 0.26 | 0.33 | 0.25 | 0.14 | 0.11 |
AST/ALT, alanine aminotransferase/aspartate aminotransferase; MCV, mean corpuscular volume; GGT, γ-glutamyl transpeptidase; ANI, ALD/nonalcoholic fatty liver disease (NAFLD) index; ALD, alcoholic liver disease; AUROC, area under the receiver operating characteristic curve; CI, confidence interval; NA, not available; PPV, positive predictive value; NPV, negative predictive value; PLR, positive likelihood ratio; NLR, negative likelihood ratio.
There were no significant difference between AST/ALT, MCV, and GGT (AST/ALT vs. MCV or GGT, MCV vs. GGT; Z = 0.276, p = 0.783; Z = 0.255, p = 0.799; Z = 0.025, p = 0.980, respectively).
There were statistically difference between ANI and AST/ALT, MCV, GGT (ANI vs. AST/ALT, MCV or GGT; Z = 3.473, p < 0.001; Z = 3.890, p < 0.001; Z = 2.867, p < 0.001, respectively).
There was statistically difference between ANI and ANI combined with GGT (Z = 2.415, p = 0.016).